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DIAGNOSTIC TESTS THAT COMPLEMENT NIPT FULL LINE OF DIAGNOSTIC TESTS Sequenom Laboratories o ers a line of laboratory-developed tests to help meet all of your prenatal testing needs. Noninvasive prenatal testing (NIPT) has proven to be a valuable resource; however, prenatal diagnosis through invasive sampling remains an important part of prenatal diagnosis. NEXTVIEW ARRAY TEST • Performed directly on uncultured amniotic fl uid or CVS tissue for the fastest overall turnaround time • High resolution SNP (single-nucleotide polymorphism) array detects numeric and unbalanced structural abnormalities, microdeletion/duplication syndromes, and large stretches of homozygosity, which can indicate shared ancestry or uniparental disomy (UPD) • SNP analysis enables detection of triploidy, mosaicism, and maternal cell contamination NEXTVIEW KARYOTYPE TEST • Conventional cytogenetic analysis for detecting numeric and large structural abnormalities, plus balanced rearrangements NEXTVIEW KARYOTYPE TEST, WITH REFLEX TO NEXTVIEW ARRAY TEST • Conventional cytogenetic analysis followed by a SNP array. Includes alpha fetal protein (AFP) analysis for screening of open neural tube defects and abdominal wall defects NEXTVIEW FISH TEST • Rapid interphase FISH assay for detection of aneuploidy of chromosomes 21, 18, 13, X and Y NEXTVIEW MATERNAL CELL CONTAMINATION TEST • Molecular assay to detect the presence of maternal cells in the fetal sample, which may obscure fetal results NEXTVIEW DIAGNOSTIC TEST PLATFORM Laboratory-developed Test Specimen Type Specimen Requirement Turnaround Time NextView Array Amniotic fl uid or CVS tissue 5-10 mg cleaned CVS tissue or 15 mL amniotic fl uid 5-7 days NextView Karyotype Amniotic fl uid or CVS tissue 15 mL amniotic fl uid and 2 mL amniotic fl uid for AFP/ AChe (17 mL) or 5-10 mg cleaned CVS tissue 8-10 days NextView Karyotype Refl ex to NextView Array Amniocytes or cultured CVS tissue 25 mL amniotic fl uid or 5-10 mg cleaned CVS tissue 8-10 days NextView FISH Amniotic fl uid or CVS tissue 5-10 mg cleaned CVS tissue or 5 mL amniotic fl uid 24-48 hours NextView Maternal Cell Contamination Maternal blood 4 mL EDTA (purple top) tubes 14 days

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